Signaling
[대역어] None
[용어속성] Term
[용어속성] Term
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway
Article
[키워드] acute lung injury
analyzed
Anti-inflammation
Apoptosis
approved
attenuate
BALF
Bcl-xL
caspase
Cell
changes
China
confocal microscope
coronavirus
COVID-19
declined
downstream
drug
Effect
expression
fatal complication
flow cytometry
food
Granule
H1N1 influenza
histological
histopathological
IL-1β
IL-6
immunofluorescence
Infectious disease
Influenza virus
inhibited
injection
intrinsic
investigated
Jinhua Qinggan granules
LPS
lung
Lung injury
Lungs
material
mechanism
mice
Mild
mitochondrial apoptotic pathway
moderate
morbidity and mortality
MPO
neutrophil
Neutrophil apoptosis
novel coronavirus disease
Nuclear factor kappa-B
nuclei
p65
pathway
pharmacological
positive
proportion
Protein
protein concentration
protein expression
pulmonary inflammation
receptor
reduced
Respiratory disease
Respiratory virus infection
Signaling
signaling pathway
significantly
staining
survival
survival rate
TLR4
TNF-α
Toll-like receptor 4.
treated
Treatment
were assessed
were measured
[DOI] 10.1016/j.jep.2022.115763 PMC 바로가기
[DOI] 10.1016/j.jep.2022.115763 PMC 바로가기
Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice
Article
[키워드] acute lung injury
acute respiratory distress
acute respiratory distress syndrome
alleviate
Analysis
Anti-inflammatory
anti-inflammatory property
anti-inflammatory response
ARDS
CFZ
Clofazimine
coronavirus disease
COVID-19
Critical
decrease
disease
Diseases
distress
down-regulate
histological change
hyperimmune response
IL-1β
immune
IMPROVE
increasingly
Infectious disease
Inflammatory
information
inhibit
involved
lipopolysaccharide
LPS
lung
Lung injury
Macrophage
macrophages
mechanism
mice
Molecular biology
pathway
pharmacological mechanism
potential molecular
profile
proliferation
protective effect
Protein
protein expression
Proteomic analysis
proteomics
proteomics.
Pulmonary edema
Quantitative
Signal transduction
Signaling
significantly
survival rate
syndrome
therapeutic strategy
TNF-α
[DOI] 10.1007/s00011-022-01623-w PMC 바로가기
[DOI] 10.1007/s00011-022-01623-w PMC 바로가기
Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway
Article
[키워드] abrogate
activated
addition
bind
binding
biological significance
cellular processe
complex
disrupt
DNA
Epigenetic
Evidence
expression
favor
Gene Expression
HDAC2
Host
host antiviral response
IFN response
IFN signaling pathway
IFN-stimulated genes
IFNβ
IL-1β
IL-6
immune response gene
inhibit
inhibition
inhibitory
interact
Interaction
interferons
involved
IRF3
nsp5
over
Pathogenesis
pathway
promote
promoter
promoters
protease
Protease activity
protein interaction
protein-protein interactions
reduce
Regulation
Replication
repress
required
RNA
SARS-CoV-2
SARS-CoV-2 protein
Signaling
signaling pathway
significantly
subset
Type
Type I IFN
type I IFN signaling.
type I interferon
viral infection
viral infections
Viral protein
virus
[DOI] 10.1128/spectrum.02322-22 PMC 바로가기
[DOI] 10.1128/spectrum.02322-22 PMC 바로가기
An explainable model of host genetic interactions linked to COVID-19 severity
Article
[키워드] age and gender
Analysis
classifiers
Cohort
contributing to
covariates
COVID-19
COVID-19 severity
dataset
Factor
Features
Follow-up
Genetic
GWAS
high accuracy
highest
Host
identify
immune pathways
immune system
increased risk
Inflammatory
Interaction
Italian patients
MCC
molecular mechanism
offer
outcome
Patient
phenotypic
predict
predicted
Predictive
screened
several variant
Severe COVID-19 Infection
severity
Signaling
significantly
Stratification
stratified
Support
tested
therapeutic intervention
Thoracic
variant
viral infection
WES
with COVID-19
[DOI] 10.1038/s42003-022-04073-6 PMC 바로가기
[DOI] 10.1038/s42003-022-04073-6 PMC 바로가기
The pH Robustness of Bacterial Sensing
Article
[키워드] analyzed
appear
Bacteria
Bacterial
bacterial adaptation
binding
can be used
change
chaperone
chemoreceptor
chemotaxis
condition
conditions
COVID-19 pandemic
cytosolic
demonstrated
demonstration
determine
dimeric
domain
eight
energy
Escherichia coli
extreme
facilitate
form
Hormones
in vivo
include
information
intrinsic
isothermal titration calorimetry
Ligand
ligands
mechanism
MONITOR
Neurotransmitters
nine
pathway
periplasmic
pH
pH robustness
pH value
progression
Protein
Proteins
Pseudomonas aeruginosa
quorum-sensing
receptors
recognize
reported
Research
resonance
respond
response
reveal
robustness
sensing
sensor domains
signal
Signal transduction
signal transduction.
Signaling
TAR
tested
ultracentrifugation
was obtained
[DOI] 10.1128/mbio.01650-22 PMC 바로가기
[DOI] 10.1128/mbio.01650-22 PMC 바로가기
Vitamin D enhances type I IFN signaling in COVID-19 patients
Article
[키워드] 95% confidence interval
adjusted hazard ratio
Admission
all-cause mortality
antimicrobial peptide
Antiviral
Antiviral effect
antiviral response
collected
COVID-19 infection
COVID-19 patient
ENhance
Host
host response
IFN
in vitro
intensive care
interferon
investigated
ISGs
JAK-STAT signaling pathway
lower risk
modulate
on type
outcome
patient survival
patients
PBMC
protein level
Regulatory
saliva specimen
SARS-CoV-2
SARS-COV-2 infection
severe COVID-19 patient
Signaling
significantly higher
treated
treated patient
treated patients
Treatment
Type I IFN
untreated patient
Vitamin D
Whole blood
[DOI] 10.1038/s41598-022-22307-9 PMC 바로가기
[DOI] 10.1038/s41598-022-22307-9 PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1
Article
Published on
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 유전자 메커니즘,
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 유전자 메커니즘,
[키워드] ABCE1
abort
acute respiratory syndrome
affecting
AKT
Alzheimer’s disease
autophagy
biochemical analysis
combating
condition
coronavirus
COVID-19 pandemic
Critical
disease
Diseases
Drosophila
effective
exhibited
Factors
Genetic
Host
hosts
mechanism
modify
neurodegenerative
nonstructural protein 1
nsp1
overexpression
pathogenic mechanism
phenotype
prevention
Protein
Quality control
quality-control
rescued
Research
ribosome collision
ribosome-associated quality control.
ribosomes
SARS-CoV-2
Signaling
specificity
therapeutic strategy
translation
Treatment
virus
[DOI] 10.1073/pnas.2202322119 PMC 바로가기
[DOI] 10.1073/pnas.2202322119 PMC 바로가기
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
Article
[키워드] cause
Cell
Cluster
Dengue
dengue virus
disease-associated
functional variant
genome-wide association
Genome-wide association study
GWAS
Human genetics
identify
indicated
individuals
Infection
iPSC array
isogenic hiPSC lines
leakage of mtDNA
locus
Loss
mitochondrial
mtDNA
NDUFA4
non-risk allele
polymorphism
provide
risk
risk allele
SARS-CoV-2
SARS-COV-2 infection
screening strategy
sensitivity
Signaling
single-nucleotide
single-nucleotide polymorphism
SNP
SNPs
Stress
susceptibility
type I interferon
type I interferon.
upregulation
viral infection
viral infectivity
virus
Zika virus
ZIKV
[DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기
[DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기
Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer
Article
[키워드] acute respiratory syndrome
AKT
Cancer
Cell
Comorbidity
coronavirus
coronavirus disease
COVID-19
de novo
death
deregulated
drug
Drug discovery
Evidence
feedback
homeostasis
homeostatic
Infection
Interaction
maintain
mechanism
opposite
pandemic
pathogen
pathway
Pathways
progression
recent
reduce
regulate
Regulation
response
responsible
SARS-CoV
SARS-CoV-2
SARS-COV-2 infection
shown
Signaling
signaling cascade
significantly
survival
therapeutic purposes
Topic
Treatment
UPR
viral infection
viral infections
[DOI] 10.1038/s41419-022-05250-5 PMC 바로가기
[DOI] 10.1038/s41419-022-05250-5 PMC 바로가기